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Compared with the rapid translocation of Nrf2 induced by DEM, NFT treatment resulted in a rather slow, but constant rise in the intensity of nuclear Nrf2 signals (Fig

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Key quantitative findings included dose-dependent increases in CXXC5 expression following PGD2 treatment, corresponding decreases in beta-catenin and PCNA (a proliferation marker), restoration of Wnt signaling and cellular proliferation with PTD-DBM treatment, and complete resistance to PGD2-induced hair loss in CXXC5 knockout mice