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Effectiveness : Semaglutide has proven results backed by clinical studies, while OTC supplements often rely on anecdotal evidence

However, it is important to acknowledge that individual patient experiences may vary, and post-marketing surveillance continues to monitor for adverse effects not detected in controlled trials

The most common adverse events were nausea (~30%), diarrhea (~20%), constipation (~15%) and vomiting (~10%)

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The gradual escalation principle may still apply in some cases, especially if side effects were previously experienced