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Beyond repurposing existing drugs, Nrf2 activators (e.g., Dimethyl Fumarate) are particularly promising as they upstreamly regulate a network of antioxidant genes, including SLC7A11, GPX4, HO-1, and FTH1, thus simultaneously bolstering defenses against multiple drivers of ferroptosis ( Table 2 ) (176)

Other serious side effects can include dizziness or lightheadedness, swelling in the feet or ankles, severe shortness of breath or wheezing, chest pain or a fast heart rate, and bright red blood in the stools

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In this study, we investigated the regulation of the TSS pathway in SCD erythroblasts under hypoxia and excess hemin exposure conditions

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After rainwater falls onto land, it dissolves minerals in rock and soil, which increases its salinity