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Purine nucleoside phosphorylase (PNP) is significantly increased in IBS-C and IBS-D patients, however, it is negatively correlated with hypoxanthine concentration (Mars et al., 2020)

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Liraglutide, a glucagon-like peptide 1 receptor agonist, exerts analgesic, anti-inflammatory and anti-degradative actions in osteoarthritis

Patients taking levothyroxine (if they have developed hypothyroidism post-treatment for Graves' disease) should take it consistently, ideally on an empty stomach in the morning, and thyroid function should be monitored to ensure adequate replacement