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Rapid weight loss without adequate protein leads to muscle loss, which slows metabolism and creates the "skinny fat" outcome where the scale looks good but body composition tells a disappointing story

Patients with a history of gastroparesis, irritable bowel syndrome, or frequent acid reflux should discuss this in detail, as semaglutides gastric-slowing effects can interact with these conditions

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They are small chains of amino acidsessentially fragments of proteinsthat act as powerful signaling molecules in the body

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Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)