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in these cases, cobalamin supplementation may be necessary [30]

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Of these trials, four compared DPP-4 inhibitors against placebo (SAVOR-TIMI 53, EXAMINE, TECOS, CARMELINA), eight compared GLP-1RA against placebo (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, REWIND, PIONEER 6, AMPLITUTE-O) and eleven compared SGLT-2 inhibitors against placebo (EMPA-REG, CANVAS, DECLARE, CREDENCE, DAPA-HF, DAPA CKD, VERTIS-CV, EMPEROR-R, SCORED, SOLOIST-WHF, EMPEROR-P)

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Malnutrition Deficient food intake, inadequate alimentary regimes, strong dietary restrictions and a general lack of nutrients result in loss of both body weight and physical performance, delayed puberty, lengthening of the post-partum interval to conception, lower gonadotropin secretion levels with alterations of the physiological ovarian cyclicity and increased infertility

Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature