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New England Journal of Medicine, Aug 14, 2025

Nakamura R, Okunuki H, Ishida S, et al

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With respect to hepatotoxicity, animal studies have demonstrated that high doses of quercetin can markedly elevate serum transaminase levels and induce lipid peroxidation as well as glutathione depletion in hepatic tissues (Singh et al., 2021), indicating that excessive quercetin intake may contribute to hepatocellular injury by activating oxidative stress pathways