Based on the assumption of an average haematocrit of 45%, 100 l whole blood contains ~55l plasma, which is ~18-fold less than the 1 ml for which the cartridge is approved
This observation has raised concerns regarding suboptimal drug exposure, altered pharmacokinetics, and heightened inflammatory burden in obese patients, highlighting the potential need for dose optimization or alternative treatment strategies in this population ( The impact of BMI on treatment response is well illustrated by the AQUILA study, which examined real-world outcomes in PsA patients treated with (65).In this cohort, obese individuals exhibited higher circulating levels of IL-17, supporting the concept that IL-17driven inflammation may be particularly prominent in this subgroup and may contribute to increased disease activity and reduced therapeutic responsiveness (66)
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What the 2026 Research Actually Shows A systematic review and meta-analysis published in Cureus in April 2026 pooled data from multiple randomised controlled trials of GLP-1 receptor agonists specifically in women with PMOS
And I had electric shocks