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(1.6) Limitations of Use: Effectiveness has not been established in patients who have lost response to or were intolerant to TNF blockers

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In addition, genetic variation in taste receptors has been linked to body weight regulation

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In higher-dose groups, the fat-loss effect seemed to continue up to 48 weeks without clear plateauing meaning more long-term metabolic benefit may still exist

Moreno YF, Sgarbieri VC, da Silva MN, Toro AA, Vilela MM (febrero de 2006)