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[DOI] [PubMed] [Google Scholar] 53.Linkova N.S., Drobintseva A.O., Orlova O.A., Kuznetsova E.P., Polyakova V.O., Kvetnoy I.M., Khavinson V.K

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Gluconeogenesis from glycerol but not from pyruvate is elevated in Insr P1195L/ + /HFD mice P1195L/ + Because severe insulin resistance in Insr P1195L/ +/HFD mice suggested unsuppressed gluconeogenesis in an otherwise insulin resistant liver, as is found in liver-specific Insr knockout (LIRKO) mice 7 , mRNA expressions of two key enzymes, phosphoenolpyruvate carboxykinase 1 ( Pck1 ) and glucose-6-phosphatase ( G6pc ), were examined (Fig