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Additionally, Fe 3+ can be reduced to Fe 2+ via oxidizing GSH, accompanying the production of OH through a Fenton-like reaction

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Lu H-C, Mackie K

599 The interlaminar astrocytes (which populate brains of high primates and are not present in other species 32,33 ) are highly vulnerable to AD pathology: at the advanced stages of the disease interlaminar astrocytes disappear, 600 although how this impacts on the disease pathophysiology remains unknown

The overlap interest is in supporting a more organized repair process rather than disorganized scar formation