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This class of medications has also been discussed in the context of li pi ds

But combining evidence-based ideas does not automatically make the entire program evidence-based

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Several weight-independent mechanisms may contribute to the cardioprotective effects of GLP-1RAs, including direct vascular and myocardial effects [29], improved plaque stability [29], anti-inflammatory benefits [30], and modulation of prothrombotic [31] and neurohormonal activity [15]

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Following a subgroup analysis for the FINGER prevention trial that showed that the beneficial cognitive effects of the multicomponent intervention were enhanced among APOE4 carriers (Solomon et al., 2018), a subsequent trial evaluating the FINGER multidomain lifestyle intervention in combination with metformin, a diabetes drug, was enriched for APOE4 carriers (Barbera et al., 2024)