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functional effects persist 6-8 hours via downstream gene expression ~3-8 hours (terminal, varies by clearance) ~5 hours (IGF-1 elevation lasts ~24h) ~30 min plasma (functional anti-inflammatory activity persists 4-6 hours) 4 hours in rats (IP)

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Elderly patients (age 65+): Seizure risk with bupropion does not appear to be age-dependent in published data, but reduced renal function and polypharmacy are more common

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SGLT1 is expressed in pancreatic cells and regulates glucagon secretion