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Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis

431,432,433 Numerous BET inhibitors, including pan-BET bromodomain inhibitors (such as JQ1, I-BET151, birabresib, mivebresib, and ZEN-3694) and selective inhibitors (such as ABBV-744, molibresib, and PLX2853), have been demonstrated to have antitumor effects in preclinical models

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Cheraghi E, Mehranjani MS, Shariatzadeh MA, Esfahani MH, Ebrahimi Z

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