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The effect of tachyphylaxis has considerable clinical significance in the context of perioperative care

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Rates of serious adverse events possibly or probably related to study drug were 2.5% with 0.1 mg of semaglutide, 3.8% with 0.2 mg, 2.5% with 0.4 mg, and 1.3% with placebo

Solomon et al., 2018)