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However, numerous studies indicate that individuals with ME/CFS experience increased intestinal permeability, supporting the theory that Gram-negative bacterial endotoxins, also known as LPS, may enter the mesenteric lymph nodes and the blood stream through the loosening of tight-junction proteins (e.g., Zonulin), triggering an immune response and resulting in systemic inflammation [10, 21, 24, 39,40,41,42]

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Why This Matters More Than Diet Alone You can follow the most perfect SIBO diet and still never recover if motility isnt really restored because if the environment doesnt change, the overgrowth returns

Int J Med Microbiol 300:5762

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