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Although the mechanisms by which these reagents modulate GPx1 expression are not clear, it has been shown that GPx1 can be upregulated by activation of the peroxisome proliferator-activated receptor--coactivator-1a (PGC1) pathway, possibly via the subsequent activation of Nrf2 [161]

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10.1007/s00284-014-0519-6 Curr

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While individual biochemistry varies, the anecdotal feedback from thousands of longevity and fitness advocates paints a very clear picture of what you can expect when utilizing these advanced splice variants