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Evidence from experiments employing somatostatin receptor 2 (SSRT2) antagonists and SSRT2 knockout mice strongly suggests that GLP-1s inhibitory actions on -cells are indirect and partially mediated through somatostatin-dependent mechanisms (132)

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None of these programs is expected to reach regulatory submission before 2028-2029 at the earliest, giving orforglipron a substantial first-mover advantage in the oral non-peptide GLP-1 space