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During exercise, serotonin levels rise and can make you feel more fatigued, meaning you won't be able to push as hard

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Appetite signals may feel unpredictable, energy levels may dip, and progress can stall even when consistent effort is being made

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While exenatide provides clinically meaningful glycemic control, its impact on weight loss is relatively modest compared to more recent GLP-1R agents, resulting in less than 3 kg of weight reduction over a 30-week period (DeFronzo et al., 2005

Unlike existing approved therapies, it simultaneously targets GLP-1, GIP, and glucagon receptors, a mechanism that early clinical data suggest may produce substantial metabolic effects