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In March 2026, the FDA approved a new high-dose formulation of semaglutide ( Wegovy HD 7.2 mg )

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Because without enough protein and calories, the body simply does not have the raw materials needed to maintain lean tissue effectively during weight loss

This receptor selectivity profile is the key pharmacological distinction between the two analogues, and makes MT-1 the reference compound in studies focused specifically on the MC1R/pigmentation axis without the confounding MC3R (energy homeostasis) and MC4R (appetite, sexual function) activity associated with MT-2

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When you lose weight rapidly, a significant portion of that loss comes from lean tissue, not just fat