OBrien R, OMalley D (2020) The glucagon-like peptide-1 receptor agonist, exendin-4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of irritable bowel syndrome
For all the excitement, the story is still unsettled
This means that food will spend more time moving through the digestive system which can increase the gut bacteria that produces gas
However, an unphysiologically large postprandial release of GLP1, for example, after gastric bypass surgery (Korner et al., 2007), might reach the circumventricular organs, and DPP4resistant GLP1 receptor agonists clearly have central actions, though whether this includes action on GLP1 receptors inside the BBB or is limited to direct activation of GLP1 receptors in the circumventricular organs outside the BBB, is less clear (Adams et al., 2018
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These changes help people feel fuller, but they can also disturb normal digestion in some individuals