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SURPASS-2 (NCT03987919) fue un estudio de 40 semanas que compar la eficacia y seguridad de Mounjaro de 5 mg (N=470), 10 mg (N=469) y 15 mg (N=469) con semaglutida inyectable de 1 mg (N=468) en adultos con diabetes tipo 2 controlada inadecuadamente con =1500 mg por da de metformina solamente

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Despite having a higher rate of SAH than IVT, it may be associated with a higher rate of early neurological improvement, with no significant differences in mid-term functional prognosis

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At about a 3 year time point, semaglutide (Wegovy and Ozempic) appears to be a safe medication with relatively minimal GI side-effects

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