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constipation (6% vs 4%)

KAT6A is a large 2004 aa protein containing multiple functional protein domains (Fig 1A)

Oxidative stress induces MPT by targeting specific cysteine residues of cyclophillin D, which results in mitochondrial depolarization, oxidative phosphorylation uncoupling, release of intra-mitochondrial ions and metabolic intermediates, mitochondrial swelling and decrease in ATP synthesis

It degrades reduced GSH, an important antioxidant, into cysteinylglycine and 5-oxoproline, thereby decreasing the cellular antioxidant defense and increasing oxidative stress