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Amylin is a neuropeptide co-secreted with insulin by pancreatic beta-cells which slows gastric emptying, and decreases food intake ( Neuropeptide Y receptor type 2 (Y2R) Peptide YY (PYY) is secreted post-prandially by the L-cells of the gut together with GLP-1 ( Melanocortin 4 receptor (MC4R) MC4R have been involved in food intake, metabolism, sexual behavior, and male erectile function ( Cannabinoid receptor 1 (CB1R) The CB1R is a G-protein coupled receptor highly expressed in the central nervous system

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A negative feedback transcription cycle is eventually formed to maintain the oscillation of the gene expression (Kiyohara et al., 2006