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Acknowledgements This work was created as part of NCCR Catalysis, a National Centre of Competence in Research funded by the Swiss National Science Foundation (grant number 180544 to R.M.B) and by AEI (Spain) (grant number RTI2018-099592-B-C22 to G.J.-O)

Dose is calculated in mg of GS-441524 per kg of body weight the B12 component does not alter the dose calculation

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Put together, this is a formula built around the idea of gradual, compounding support rather than an immediate jolt

[2] le Roux CW, et al

Cancer Res 82(13):23882402 Zhang C, Quinones A, Le A (2022b) Metabolic reservoir cycles in cancer