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2012), led us to propose that hepsin could significantly diminish the severity of APAP-induced hepatotoxicity by regulating the abundance of hepatic GJ proteins, which may alter the distribution of free radicals between neighboring hepatocytes, thereby potentially increasing oxidative stress

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A key innovation of this review lies in integrating recent advances, especially those highlighting the roles of epigenetic modifications, mitochondrial dysfunction, and insulin resistance (IR)-related pathways in spermatogenesis

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