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Targeting NRF2 sensitizes esophageal adenocarcinoma cells to cisplatin through induction of ferroptosis and apoptosis

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Thus, experiments with ovariectomized (OVX) rats have shown a reduction in the anti-oxidant activity of superoxide dismutase (SOD) in the hippocampus, a process that contrasts with an increase in the pro-oxidant enzyme monoamine oxidase (MAO) in the same region (Huang and Zhang, 2010)