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Activation of FXR in dendritic cells, macrophages, and natural killer T (NKT) cells suppresses the NF-B and NLRP3 inflammasome pathways, thereby attenuating the secretion of pro-inflammatory cytokines (e.g., TNF-, IL-6, and IL-1) while promoting the release of the anti-inflammatory mediator IL-10
Minimizing the eccentric components of resistance exercise reduces muscle microtrauma during flare-ups [46, 50, 104]
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