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Patients with hypothalamopituitary disconnection showed complete blockade of the GHRP-6 response, confirming the importance of the hypothalamic pathway

References: Katzung BG (2021): Introduction to Autonomic Pharmacology (Chapter 6)

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Therefore, PYY plays an indispensable role in improving obesity, metabolic syndrome, and insulin resistance, and its development as a therapeutic agent for insulin resistance shows great promise