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All samples were then analyzed by high performance liquid chromatography/mass spectrometry

Managing Digestive Side Effects of GLP-1 To reduce the risk of constipation and digestive discomfort: Stay hydrated Eat fiber-rich foods Increase fiber gradually Stay physically active Follow your prescribed dosing schedule These steps may help support healthier digestion while using GLP-1 medications

doi: 10.1038/tp.2015.19 35 JanickovaLRechbergerKFWeyLSchwallerB

Simon Classification Simon classification is based on the degree of tissue and skin excess

Symptoms during the first 24 hours are not diagnostic or specific and include nausea, vomiting, diaphoresis, anorexia, and lethargy, the severity of which will be in direct correlation to the size of the dose ingested

Consuming smaller, more frequent portions and choosing cold or room-temperature options may help manage nausea