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In turn, NHE1 promotes cell volume expansion, which increases membrane tension, resulting in TRPV4-mediated calcium influx and the activation of actomyosin contractility [161]

Yet in most patients this GI distress is not severe enough to stop treatment, though it is reported in approximately 40% of patients (compared to 20% on placebo)

Elkalla N, Elhamammsy MH, Bedair NI, Elazazy O, El Kholy AA

When multiple publications originated from the same clinical research program, the most recent or most comprehensive report was used as the primary source

Consistent complaints about poor communication, unsafe products, or unprofessional behavior are warning signs

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