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Conclusions and future directions This review underscores the complex, bidirectional relationship between depression and diabetes, highlighting how each condition can exacerbate the other, complicating management and adversely impacting clinical outcomes

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A meta-analysis of 56 studies examining MTHFR C677T in patients and control subjects indicated that the T allele and TT genotype carriers showed significant increased risk of major psychiatric disorders including schizophrenia and bipolar disorder 63

doi: 10.3390/nu12020334 134 Garca-GarcaFJMonistrol-MulaACardellachFGarrabouG