Dehydration and Electrolyte Imbalance : Gastrointestinal side effectsespecially nausea, vomiting, and diarrheacan lead to fluid and electrolyte losses
You also get histamine from food especially things like: Aged cheeses Wine and beer Cured or smoked meats Fermented foods (sauerkraut, soy sauce, kombucha) Tomatoes, spinach, avocados Leftovers (yes, really!) Normally, your body breaks down histamine using an enzyme called DAO (diamine oxidase)
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Since HNMT (the intracellular histamine-degrading enzyme) requires SAMe, impaired methylation can slow histamine clearance, especially in tissues like the brain and airways, where HNMT is the primary clearance pathway
Intestinal glutamate metabolism
What sets Tirzepatide apart from existing medications is its dual-incretin mechanism of action