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245 E3 ligases from the NEDD4 family, such as NEDD4-2, SMURF1, SMURF2, and WWP1, are key regulators of this pathway

The retina is especially vulnerable to oxidative stress due to its high oxygen exposure and high concentration of polyunsaturated fatty acids

A dose-dependent decrease in body weight was shown, ranging from -1.3 kg in the placebo group to -1.4 kg in the 0.03 mg/kg leptin-treated group, and to -7.1 kg in the 0.30 mg/kg leptin-treated group (8)