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The Washington Post

Recently, over-the-counter dietary supplements that dont require a prescription have hit the market, including Kourtney Kardashians Lemme GLP-1 Daily, which claims to naturally boost GLP-1 levels in the body to reduce hunger and support healthy weight management

Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]

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NLRP3 inflammasome activation induced by hyperglycemia can cause endothelial dysfunction in T2DM

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