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Concurrent with the rising number of cases of EOCRC, the burden of metabolic diseases, particularly obesity and type 2 diabetes mellitus (T2DM), has surged among young populations

154 However, HIF-1 in islets is decreased in T2D, by hyperglycemia through inhibiting the HIF-1-HIF-1 dimer formation, and by NEFAs through increasing the proteolysis, leading to inability to initiate hypoxic adaptive responses

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doi: 10.1007/s12020-013-0073-1 41 Ben-JonathanNHugoERBrandebourgTDLaPenseeCR

For the 4 mg maintenance dose, escalation ends at week 5