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I.MarceauG.BernardM.BourbonnireL.et al (2011)

Both substances lower blood sugar and slow digestion, which can increase the risk of hypoglycemia and severe gastrointestinal side effects

The lower set point for blood glucose in mice transplanted with human or cynomolgus monkey islets was independent from the islet mass transplanted, but depended on the donor islet species and is therefore likely to be dependent on islet composition [56]

Missing occasional doses is not catastrophic given TB-500's longer half-life