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A 2025 Cleveland Clinic study found that individuals with certain genetic profiles were up to 50% more likely not to lose weight on GLP-1 medications, while those with responsive profiles were up to 82% more likely to achieve significant weight loss

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Retatrutide has shown even more impressive results in its initial Phase II trial

Chen TH, Lee MMY, Docherty KF, et al

Some patients use intensive initial protocols followed by maintenance phases or periodic cycles for sustained cognitive optimization

In healthy individuals, these events facilitate the recovery, which is associated with the switch from M1 to M2 anti-inflammatory phenotype of macrophages population