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Medications: Both prescription and over-the-counter drugs can lower glutathione status

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Compared to molecules that are randomly distributed in the cytoplasm, drug molecules concentrated in subcellular compartments are more difficult to excrete, which improves the bioavailability of drugs while reducing the development of drug resistance [82, 83]

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This relationship creates a destructive cycle: stress lowers BDNF, which impairs the hippocampal circuits that regulate stress responses, which leads to more cortisol production and further BDNF reduction