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[118] Methionine synthase [edit] Methionine synthase, coded by MTR gene, is a methyltransferase enzyme which uses the MeB 12 and reaction type 2 to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine

B12 is important in making the myelin sheath, which transmits the nerve impulses

Because of these challenges, many experts agree that the arm is a site best left to a trained provider who can administer the injection safely and correctly

While B12 is naturally present in animal-based foods such as meat, fish, and dairy, many people struggle to get adequate amounts due to dietary restrictions, absorption issues, or certain medical conditions

The same studies can be located independently on PubMed using the CAS number (221231-10-3) or the compound name

The PRISMA statement for reporting systematic and metaanalyses of studies that evaluate interventions: explanation and elaboration