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2ik), largely overlapping with the distribution of GLP-1R neurons in lamina VIII

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This pattern differs from that of older peptides, which stimulate both lactotrophs and somatotrophs

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In the Phase 3 TRIUMPH-1 trial reported in May 2026, participants on the 12 mg dose lost an average of 28.3% of their body weight at 80 weeks, with some continuing past 30% on the 104-week extension