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Slowing gastric emptying and reducing appetite Decreasing postprandial and fasting glucose, as well as serum triglycerides Pharmacokinetics Synthetic GLP-1 agonists are resistant to degradation by DPP-4 , giving them a longer half-life than endogenous GLP-1

The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice

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Effects of Other Drugs on Sitagliptin Clinical data described below suggest that sitagliptin is not susceptible to clinically meaningful interactions by co-administered medications