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Original Publication Date: January 23, 2024 Last Updated: May 16, 2024 These data come from Cosmos, a collaboration of 236 Epic health systems representing more than 227 million patient records from 1,301 hospitals and more than 28,600 clinics from all 50 states and Lebanon

Important safety considerations include: Risk of pancreatitis : Seek urgent medical attention for severe, persistent abdominal pain (which may radiate to the back), with or without vomiting Gallbladder disease : Be aware of symptoms such as right upper quadrant pain, fever, or jaundice Diabetic retinopathy : Patients with pre-existing retinopathy should have appropriate monitoring Hypoglycaemia risk : When used with insulin or sulfonylureas, dose adjustments of these medications may be needed Oral contraceptives : The effectiveness of oral contraceptives may be reduced

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No sugar : Fizzy drinks, cakes and sweets are avoided

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