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However, these events are not without redox consequences, as shown here

RP primarily results from radiation-induced DNA damage, oxidative stress, and dysregulated TGF- signaling, which collectively contribute to the development of pulmonary fibrosis

In another double-blind, placebo-controlled trial, an improvement in cognitive performance (i.e., MMSE score) was reported in AD patients randomized to receive 800 IU/day of all - rac --tocopherol (360 mg/day of RRR --tocopherol) for six months only when the treatment effectively reduced oxidative stress (as assessed by the measure of total glutathione and markers of lipid peroxidation in the blood) (110)

Oxidative stress, inflammation, and mitochondrial dysfunction were identified in these brain regions, suggesting they are the root causes of the observed neurochemical and histopathological changes (Mazumder et al., 2019)

(Academic Press, 2022)

Targeting these genes to induce ferroptosis may be a new therapy for prostate cancer