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D., & Winters, R

A 2022 study demonstrated that if endometriosis were funded at the same level as diabetes in relation to its annual economic burden in the US, its NIH funding would need to increase to $298.8-$455.3m

Additionally, hemin (a porphyria therapeutic agent) has been shown to upregulate GPX4 via the HO-1/NRF2 signaling pathway, thereby inhibiting oxidative stress and ferroptosis, which alleviates CIN (265)

Am J Clin Nutr 2008

"Like fasting," it said, "colonic cleansing carries a risk of dehydration, electrolyte imbalance, impaired bowel function, and disruption of intestinal flora." Edzard Ernst, professor of complementary medicine at Exeter University, called the concept of detoxing both a scandal and "criminal exploitation of the gullible man" in a 2014 interview with the Guardian

Ethics declarations Ethics approval and consent to participate This study was conducted in accordance with the amended Declaration of Helsinki