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Amphetamines disrupt VMAT2 function and vesicular uptake through a combination of mechanisms: The Weak Base Effect (pH Gradient Collapse) : Amphetamines are lipophilic weak bases (pKa of 9.9) that can readily diffuse across both the plasma and vesicular membranes to accumulate inside synaptic vesicles (Wimalasena 2011)
These hidden sources of histamine can unwittingly exacerbate your symptoms, leaving you feeling confused and frustrated
The clinical efficacy of infusions for many specific indications, on the other hand, is still under investigation
[Updated 2024 Apr 30]
Problems with essential fatty acids: time for a new paradigm
doi: 10.1158/0008-5472.CAN-09-1947 119
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