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The high incidence and prevalence are attributed to the ageing population and poor lifestyles (Minari et al., 2023)

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Dietary restriction is the most evolutionarily conserved method of lifespan extension 10

This paper shows that three cytoplasmic thiol-disulphide oxidoreductases (E10R, A2.5L and G4L) encoded by vaccinia virus cooperate in a cytosolic pathway for the formation of disulphide bonds in virion proteins