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In just a few days, millions of Medicare beneficiaries who have been locked out of obesity treatment could gain access to GLP-1 medications for as little as $50 per month

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The agency is not aware of any basis for compounding using the salt forms that would meet the FD&C requirements for types of active ingredients that can be compounded

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In the Phase 2 obesity trial, the 12 mg weekly dose produced a mean weight reduction of about 24.2% at 48 weeks ( Jastreboff et al., NEJM 2023 ) the largest figure reported for any single agent in the incretin class at the time

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The participants received the max dose of semaglutide: 2.4 mg injected once weekly

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Others struggle with nausea, vomiting, or stomach discomfort that makes the treatment hard to continue

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Compared to placebo it was much more effective at maintaining remission in patients who tapered off their medications (Omer 2007)

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