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Key findings from SURMOUNT-1 include a mean weight loss of 15.0% at the 5mg dose, 19.5% at the 10mg dose, and 20.9% at the 15mg dose over 72 weeks

It prevents progression of anemia and nerve damage by supplying B directly, even when intrinsic factor (the gastric protein needed for oral B12 absorption) is lacking

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The Effects of Proton Pump Inhibitors in Acid Hypersecretion-Induced Vitamin B12 Deficiency: A Systematic Review (2022)