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Severe Hypokalemia: A Critical Drop in Potassium Levels One of the most serious complications of B12 replacement therapy in severe megaloblastic anemia (a type of anemia where blood cells are abnormally large) is the development of severe hypokalemia (dangerously low potassium levels in the blood)

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Light exposure also contributes to degradation, particularly for peptides containing tryptophan, tyrosine, methionine, or cysteine residues